Ferritin L and H subunits are differentially regulated on a post‐transcriptional level
نویسندگان
چکیده
منابع مشابه
Both subunits of rat liver ferritin are regulated at a translational level by iron induction.
A few hours after administering iron to rats, liver ferritin synthesis increases several fold. However, Northern blot analysis with cDNA probes for ferritin light (L) and heavy (H) subunit mRNAs failed to show an increase in total population of either messenger. Cytoplasmic distribution of ferritin messages was therefore investigated in control and iron administered rats killed at 3.5 hours. Th...
متن کاملFerritin L and Ferritin H are differentially located within hepatic and extra hepatic organs under physiological and acute phase conditions.
Ferritin L (FTL) and Ferritin H (FTH) subunits are responsible for intercellular iron storage. We previously reported increasing amounts of liver cytoplasmic and nuclear iron content during acute phase response (APR). Aim of the present study is to demonstrate intracellular localization of ferritin subunits in liver compared with extra hepatic organs of rat under physiological and acute phase c...
متن کاملAre Regulated by Transcriptional and Posttranscriptional Processes
We investigated the chromosomal organization and developmental regulation of soybean 8-conglycinin genes. The 8-conglycinin gene family contains at least 15 members divided into two major groups encoding 2.5-kilobase and 1.7-kilobase embryo mRNAs. 8-Conglycinin genes are clustered in severa1 DNA regions and are highly homologous along their entire lengths. The two groups differ by the presence ...
متن کاملDistinct stability of recombinant L and H subunits of human ferritin: calorimetric and ANS binding studies.
Thermodynamic and pH stability of recombinant human L- and H-ferritins were probed by differential scanning calorimetry and 8-anilino-1-naphthalenesulfonate (ANS) binding in the pH range 2-7. At pH 2.0-2.8 they were dissociated into subunit monomers and in this pH interval the H-subunit displayed a single calorimetrically-revealed domain with properties of a molten globule-like state: low entha...
متن کاملSequence analysis of dolphin ferritin H and L subunits and possible iron-dependent translational control of dolphin ferritin gene
BACKGROUND Iron-storage protein, ferritin plays a central role in iron metabolism. Ferritin has dual function to store iron and segregate iron for protection of iron-catalyzed reactive oxygen species. Tissue ferritin is composed of two kinds of subunits (H: heavy chain or heart-type subunit; L: light chain or liver-type subunit). Ferritin gene expression is controlled at translational level in ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.998.3